International Journal of Medical Sciences and Education (IJMSE)
Vol. 8 Issue: 3 (July -Sept. 2021), Date of Publication: 01.10.2021
1. ASSOCIATION BETWEEN PLASMA LEVELS OF VITAMIN B12 AND HYPERTENSION 1-5
Dr. Shreya Nigoskar, Dr. Naresh Kumar PDF FULL TEXT
Dr. Shreya Nigoskar, Dr. Naresh Kumar PDF FULL TEXT
ABSTRACT
Background: Hypertension is an important community health concern all over the world, which is influenced by both genetic and environmental factors. Epidemiological studies have discovered that numerous environmental factors are linked with hypertension, such as sodium intake, obesity, physical inactivity, and alcohol consumption. Methods: The present cross-sectional prospective study was conducted at the department of Biochemistry of our tertiary care hospital. The study duration was of six months between April 2019 and March 2020. The patients were grouped into two groups 75 patients in hypertension and 75 normotensive persons based on sphygmomanometer readings. Results: The age of the subjects in the study group ranged from 20 to 50 years. The mean and standard deviation for the age of the Cases and control individuals were 27.81 ± 6.1 and 26.92 ± 5.6 respectively; there was no significant difference among the cases and controls with reference to the age. The significant difference is there in BMI, WHR, B12 level, (Mean and SD) between cases and control. Conclusion: In our study, blood levels of B12 is a conjunct parameter with Homocysteine to predict risk for CVD, the relationship between elevated vitamin B12 and CVD is causal and probably due to multiple, potentially synergistic, pathogenetic mechanisms. Measurement of blood vitamin B12 is recommended for risk assessment in CVD patients.
Keyword: Postoperative analgesia patient-controlled epidural analgesia patient-controlled intravenous analgesia.
Keyword: Postoperative analgesia patient-controlled epidural analgesia patient-controlled intravenous analgesia.
2. POSTOPERATIVE ANALGESIA AFTER MAJOR ABDOMINAL SURGERY: INFLUENCE OF FENTANYL- BUPIVACAINE PATIENT CONTROLLED EPIDURAL ANALGESIA VS FENTANYL PATIENT CONTROLLED INTRAVENOUS ANALGESIA 6-13
Dr Abeezar Hussain PDF FULL TEXT
Dr Abeezar Hussain PDF FULL TEXT
ABSTRACT
Background - Patient-controlled epidural analgesia with Local anaesthetics either alone or in combination with opioids and patient controlled analgesia with intravenous opioids are two clinical ways to tackle postoperative pain after major surgeries. This prospective, randomized clinical study was conducted to compare these two ways in regards to pain control, sedation score , overall patient satisfaction & complications after major abdominal surgeries. Methods: 70 patients with ASA grade I & II aged 25-65 yrs of either sex were randomized to EPCA group - patient-controlled epidural analgesia with fentanyl–bupivacaine IVPCA group - patient controlled intravenous analgesia with fentanyl . Parameters monitored were pain scores, rescue analgesia required, sedation scores, complications & overall patient satisfaction. Results: Both the groups were comparable with regards to demographic characteristics, hemodynamic variables at baseline, duration of surgery .While in Group IVPCA ,immediate postoperative pain was statistically significantly less observed (p<0.05). In Group EPCA , pain was statistically significantly less noted at 2hr, 4hr, 8hr & 12 hrs as compared to Group IVPCA(p<0.05) . In context to sedation scores, Group IVPCA observed higher sedation scores, at immediate postoperative period , with no difference statistically at 2, 4, 8,12 & 24 hrs (p<0.05). Minimal adverse events of nausea ,vomiting, pruritis & shivering were noted. The average overall patient satisfaction score in Group EPCA & Group IVPCA was 9 and 6 respectively. The overall patient satisfaction was statistically significantly higher in Group EPCA (p<0.05). Conclusion: Both epidural & intravenous groups were effective in postoperative pain management after major abdominal surgery . The patient controlled analgesia via epidural route provided better pain relief, less sedating effects , minimal side effects & enhanced overall patient satisfaction.
Keywords- Patient controlled analgesia ,Epidural analgesia , Intravenous analgesia , Patient satisfaction
Keywords- Patient controlled analgesia ,Epidural analgesia , Intravenous analgesia , Patient satisfaction
ABSTRACT
Chikungunya, is a vector borne disease, epidemics were reported and various studies were conducted to halt its diseases cycle and implement the vector control measures. The diseases burden is widely distributed among subtropical, tropical and monsoon zones worldwide along with cultural and socio-economic factors. Chikungunya is present as an acute illness, with fever, skin rash and incapacitating arthralgia as its salient feature.Material & Methods: The present prospective study was conducted at department of general medicine of our tertiary care hospital. The study duration was of one year and sample size of 50 was calculated at 95% confidence interval at 5% acceptable margin of error. All patients who were diagnosed with chikungunya were enrolled from outdoor department and from ward by simple random sampling. Results: In the present study, the most presenting symptom was fever and arthralgia which were present in 100% of cases which were followed by headache and body ache which was present in 98% cases, followed by nausea and vomiting in 70% cases. weakness was present among 64% patients and abdominal pain was present in 32% patients. Splenomegaly was the most common organomegaly finding, which was present in 24% patients which was followed by hepatomegaly was present in 20% patients. Among 8 patients there was both Hepato-splenomegaly present. In present study, none of patients had cardio-vascular symptoms and complications. Out of the total patients, serum urea levels were in normal limits however, serum creatinine values were higher among 8% of patients. There was no other morbidity and mortality reported in present study. Conclusion: We concluded from the present study that majority of patients had fever and arthralgia which were present in 100% of cases which were followed by headache and body ache which was present in 98% cases, followed by nausea and vomiting in 70% cases. weakness was present among 64% patients and abdominal pain was present in 32% patients.
Keywords: Chikungunya, Clinical feature, Epidemic.
Keywords: Chikungunya, Clinical feature, Epidemic.
