International Journal of Medical Sciences and Education (IJMSE)
Vol. 4; Issue: 1 (Jan-March 2017) , Date of Publication: 01.04.2017
COMPARATIVE ANALYSIS BETWEEN BONE MARROW ASPIRATION CYTOLOGY AND BONE MARROW BIOPSY EXAMINATION IN DIAGNOSIS OF LEUKEMIC PATIENTS
Dr. Shubhnita Garg, Dr. Mohammed Khushnood
ABSTRACT
Objective- bone marrow aspiration is main stay in diagnosis of leukemia. Though it is used from long time, sensitivity, diagnostic accuracy is yet not proven. So the objective of our study to find out diagnostic accuracy ,sensitivity ,specificity of bone marrow aspirate (BMA) cytology in diagnosis of leukemia and comparative diagnostic analysis of trephine biopsy with bone marrow aspirate cytology. Material And Method: In our study 30 Patients with suspected diagnosis of leukemia were included. Data was collected prospectively between Jan2015-Jan2016. The cytology smears were stained using appropriate stains. Bone marrow aspirate diagnosis and histo-pathological results of were compared and concordance was assessed. Result: In the present study we included 30 cases of leukemia in which BMA and bone marrow biopsy (BMB) was done, Out of which 19 cases were of chronic leukemia , 5 case were Acute leukemia, with mean age of 29 . Biopsy confirmation of the diagnosis was available in all the cases. Overall diagnostic sensitivity of BMA was 93.3 % for detecting malignancy. There were 02 false negative case were also diagnosed. Cyto-pathological Concordance was high in lymphocytic leukemia. Conclusion: Bone marrow aspiration is a safe and relatively non invasive procedure for diagnosis and evaluation of leukemia.
Keywords: Aspiration cytology, Bone marrow Biopsy, Leukemia.
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CERVICAL LYMPHADENOPATHY : CLINICO-PATHOLOGICAL STUDY OF 148 CASES
Saurabh Gakhar,Tarun Ojha, Kanak Yadav, Abhishek Sharma, Amit singhal , Abhay Sharma
ABSTRACT
Objective-: To study the incidence of disease in cervical lymph nodes by clinical examination and by studying pathology by fine needle aspiration cytology or excision biopsy. Method: This observational study was conducted at department of ENT Mahatma Gandhi medical college and hospital Sitapura Jaipur from June 14 to December 16 for a period of 2 and a half year .Where patients were studied for 2 years and follow up was done for 6 months. Total 148 patients were included in study. Results: Study group has 148 patients. Tuberculosis was the most common cause (44.6%) of cervical lymphadenopathy followed by reactive lymphadenopathy (28.38%); metastatic carcinoma and malignant lymphoma constitutes 18.9% and 8.1% respectively. The most common age group involved was 2nd and 3rd decade. Male patients were mostly affected in the study. The commonest size of nodal swelling was 2 – 4 cms. On examination maximum numbers of nodes affected in tuberculosis were level 5 followed by level 2. Reactive nodes were present mostly in level 2.Metastatic carcinoma submandibular and level 2 nodes were mostly involved. And lymphoma was found to be mostly involving level 2 nodes. FNAC was 90% effective in diagnosing tuberculosis patients and for the rest excision biopsy was done; while FNAC detected metastasis in all patients i.e. excision biopsy was not required. Excision biopsy done in all patients of lymphoma for purpose of immunohistochemistry. Conclusion: Tuberculosis is the most common cause of cervical lymphadenopathy followed by reactive lymphadenopathy and then by neoplastic lesions. FNAC is an effective modality for pathological diagnosis.
Keywords: Tuberculosis, Metastasis, cervical lymphadenopathy.
Dr. Shubhnita Garg, Dr. Mohammed Khushnood
ABSTRACT
Objective- bone marrow aspiration is main stay in diagnosis of leukemia. Though it is used from long time, sensitivity, diagnostic accuracy is yet not proven. So the objective of our study to find out diagnostic accuracy ,sensitivity ,specificity of bone marrow aspirate (BMA) cytology in diagnosis of leukemia and comparative diagnostic analysis of trephine biopsy with bone marrow aspirate cytology. Material And Method: In our study 30 Patients with suspected diagnosis of leukemia were included. Data was collected prospectively between Jan2015-Jan2016. The cytology smears were stained using appropriate stains. Bone marrow aspirate diagnosis and histo-pathological results of were compared and concordance was assessed. Result: In the present study we included 30 cases of leukemia in which BMA and bone marrow biopsy (BMB) was done, Out of which 19 cases were of chronic leukemia , 5 case were Acute leukemia, with mean age of 29 . Biopsy confirmation of the diagnosis was available in all the cases. Overall diagnostic sensitivity of BMA was 93.3 % for detecting malignancy. There were 02 false negative case were also diagnosed. Cyto-pathological Concordance was high in lymphocytic leukemia. Conclusion: Bone marrow aspiration is a safe and relatively non invasive procedure for diagnosis and evaluation of leukemia.
Keywords: Aspiration cytology, Bone marrow Biopsy, Leukemia.
PDF FULL TEXT
_____________________________________________________________
CERVICAL LYMPHADENOPATHY : CLINICO-PATHOLOGICAL STUDY OF 148 CASES
Saurabh Gakhar,Tarun Ojha, Kanak Yadav, Abhishek Sharma, Amit singhal , Abhay Sharma
ABSTRACT
Objective-: To study the incidence of disease in cervical lymph nodes by clinical examination and by studying pathology by fine needle aspiration cytology or excision biopsy. Method: This observational study was conducted at department of ENT Mahatma Gandhi medical college and hospital Sitapura Jaipur from June 14 to December 16 for a period of 2 and a half year .Where patients were studied for 2 years and follow up was done for 6 months. Total 148 patients were included in study. Results: Study group has 148 patients. Tuberculosis was the most common cause (44.6%) of cervical lymphadenopathy followed by reactive lymphadenopathy (28.38%); metastatic carcinoma and malignant lymphoma constitutes 18.9% and 8.1% respectively. The most common age group involved was 2nd and 3rd decade. Male patients were mostly affected in the study. The commonest size of nodal swelling was 2 – 4 cms. On examination maximum numbers of nodes affected in tuberculosis were level 5 followed by level 2. Reactive nodes were present mostly in level 2.Metastatic carcinoma submandibular and level 2 nodes were mostly involved. And lymphoma was found to be mostly involving level 2 nodes. FNAC was 90% effective in diagnosing tuberculosis patients and for the rest excision biopsy was done; while FNAC detected metastasis in all patients i.e. excision biopsy was not required. Excision biopsy done in all patients of lymphoma for purpose of immunohistochemistry. Conclusion: Tuberculosis is the most common cause of cervical lymphadenopathy followed by reactive lymphadenopathy and then by neoplastic lesions. FNAC is an effective modality for pathological diagnosis.
Keywords: Tuberculosis, Metastasis, cervical lymphadenopathy.
